Mabthera-RA 2010

Select a dilemma

1. Which of my RA patients are suitable for treatment with rituximab?

   What screening should be carried out for patients before they are given rituximab?

   • Patient profile before rituximab treatment

    

   Can rituximab be used in patients who have experienced lack of efficacy with 1 TNF inhibitor?

   • Failure on one TNF inhibitor agent in RA
   • Resolution of extra-articular manifestations of RA with rituximab treatment
   • Efficacy and safety with repeat courses of rituximab
   • Rituximab and vaccination
   • Patient profile before rituximab treatment

    

   Can rituximab be used in women of childbearing age?

   • Failure on one TNF inhibitor agent in RA
   • Efficacy and safety with repeat courses of rituximab
   • Should returning symptoms dictate the frequency of rituximab infusions ?

    

   Can rituximab be used in patients with radiographic evidence of joint damage?

   • Failure on one TNF inhibitor agent in RA
   • Repeat rituximab course for rheumatoid arthritis
   • Patient profile before rituximab treatment

    

   Can rituximab be used in patients over 65 years of age?

   • When should patients receive repeat courses of rituximab treatment?

    

   Can rituximab be used in patients with other conditions in addition to their RA?

   • Resolution of extra-articular manifestations of RA with rituximab treatment
   • When should patients receive repeat courses of rituximab treatment?
   • Rituximab for RA - a practical insight for physicians
   • Should returning symptoms dictate the frequency of rituximab infusions ?

    

   Can rituximab be used in patients that are rheumatoid factor negative?

   • Patient profile before rituximab treatment

2. What about subsequent courses of rituximab for my RA patients?

   When should subsequent courses of rituximab be given?

   • Resolution of extra-articular manifestations of RA with rituximab treatment
     
   • When should patients receive repeat courses of rituximab treatment?
   • Efficacy and safety with repeat courses of rituximab
   • Rituximab in a case of RA with sero-positive RF and anti-CCP
   • Repeat rituximab course for rheumatoid arthritis
   • Rituximab for RA - a practical insight for physicians
   • Should returning symptoms dictate the frequency of rituximab infusions ?

   
   What is the efficacy of subsequent courses of rituximab?

   • Resolution of extra-articular manifestations of RA with rituximab treatment
     
   • When should patients receive repeat courses of rituximab treatment?
   • Efficacy and safety with repeat courses of rituximab
   • Rituximab in a case of RA with sero-positive RF and anti-CCP
   • Repeat rituximab course for rheumatoid arthritis
   • Rituximab for RA - a practical insight for physicians
   • Should returning symptoms dictate the frequency of rituximab infusions ?

   
   How safe is it to receive repeat courses of rituximab?

   • Resolution of extra-articular manifestations of RA with rituximab treatment
     
   • When should patients receive repeat courses of rituximab treatment?
   • Efficacy and safety with repeat courses of rituximab
   • Rituximab in a case of RA with sero-positive RF and anti-CCP
   • Repeat rituximab course for rheumatoid arthritis
   • Rituximab for RA - a practical insight for physicians
   • Should returning symptoms dictate the frequency of rituximab infusions ?
   • Patient profile before rituximab treatment

3. What response can we expect when treating my RA patients with rituximab?

   What clinical response should I expect to observe after a course of rituximab?

   • Failure on one TNF inhibitor agent in RA
   • Resolution of extra-articular manifestations of RA with rituximab treatment
   • When should patients receive repeat courses of rituximab treatment?
   • Patient with inadequate response to TNF inhibitor agents
   • Efficacy and safety with repeat courses of rituximab
   • Rituximab and vaccination
   • Rituximab in a case of RA with sero-positive RF and anti-CCP
   • Repeat rituximab course for rheumatoid arthritis
   • Rituximab for RA - a practical insight for physicians
   • Should returning symptoms dictate the frequency of rituximab infusions ?
   • Patient profile before rituximab treatment

   
   When do I evaluate a response to a course of rituximab?

   • Failure on one TNF inhibitor agent in RA
   • Resolution of extra-articular manifestations of RA with rituximab treatment

   • When should patients receive repeat courses of rituximab treatment?

   • Efficacy and safety with repeat courses of rituximab

   • Rituximab in a case of RA with sero-positive RF and anti-CCP

    

   Should my patient expect a change in quality of life or fatigue?

   • Failure on one TNF inhibitor agent in RA

   • When should patients receive repeat courses of rituximab treatment?

   • Patient with inadequate response to TNF inhibitor agents

   • Rituximab for RA - a practical insight for physicians

   • Should returning symptoms dictate the frequency of rituximab infusions ?

    

   What is the duration of response after a single course of rituximab?

   • Failure on one TNF inhibitor agent in RA

   • When should patients receive repeat courses of rituximab treatment?

   • Efficacy and safety with repeat courses of rituximab

   • Rituximab in a case of RA with sero-positive RF and anti-CCP

   • Rituximab for RA - a practical insight for physicians

4. Should I expect any untoward reactions in my RA patients being treated with rituximab infusion?

   What are the possible reactions to the rituximab infusions?

   • Failure on one TNF inhibitor agent in RA
   • Rituximab for RA - a practical insight for physicians
   • Should returning symptoms dictate the frequency of rituximab infusions ?

   
   How can the risk of infusion reactions be minimised?

   • Failure on one TNF inhibitor agent in RA
   • Rituximab for RA - a practical insight for physicians
   • Should returning symptoms dictate the frequency of rituximab infusions ?

   How do I manage an infusion reaction?

   • Failure on one TNF inhibitor agent in RA
   • Rituximab for RA - a practical insight for physicians
   • Should returning symptoms dictate the frequency of rituximab infusions ?

   If a patient experiences an infusion reaction during the first infusion of rituximab, what will happen during subsequent infusions?

   • Failure on one TNF inhibitor agent in RA
   • Rituximab for RA - a practical insight for physicians
   • Should returning symptoms dictate the frequency of rituximab infusions ?

5. What treatment regimen of rituximab should I use for my RA patients?

   What is the recommended dosage of rituximab?

   • Failure on one TNF inhibitor agent in RA
   • Patient with inadequate response to TNF inhibitor agents
   • Rituximab in a case of RA with sero-positive RF and anti-CCP

   
   What premedication is required prior to receiving rituximab treatment?

   • Failure on one TNF inhibitor agent in RA
   • Patient with inadequate response to TNF inhibitor agents
   • Rituximab in a case of RA with sero-positive RF and anti-CCP

   
   What concurrent medication can be used in patients receiving rituximab treatment?

   • Failure on one TNF inhibitor agent in RA
   • Patient with inadequate response to TNF inhibitor agents
   • Rituximab in a case of RA with sero-positive RF and anti-CCP

6. Can rituximab be used in RA patients in special medical circumstances?

   Can rituximab be used in patients requiring vaccination?

   • Rituximab and vaccination

   
   How safe is rituximab in patients who have been treated for pulmonary tuberculosis in the past?

   • Patient profile before rituximab treatment

   
   What is the risk of reactivation of tuberculosis in a patient receiving rituximab treatment?

   • Patient profile before rituximab treatment